Applicability of Atmospheric Pressure Photoionization Mass Spectrometry to Trace Analysis of Hydrophilic Drugs
نویسندگان
چکیده
منابع مشابه
Atmospheric pressure photoionization mass spectrometry.
Atmospheric pressure photoionization (APPI) is the last arrival in the family of atmospheric pressure ionization (API) methods to couple mass spectrometry (MS) to liquid-phase separation techniques. The basic idea was to further extend the fields of application of liquid chromatography (LC)-MS to those molecules that are not, or are poorly amenable, to electrospray (ESI) or APCI. The present re...
متن کاملInfrared laser ablation atmospheric pressure photoionization mass spectrometry.
In this paper we introduce laser ablation atmospheric pressure photoionization (LAAPPI), a novel atmospheric pressure ion source for mass spectrometry. In LAAPPI the analytes are ablated from water-rich solid samples or from aqueous solutions with an infrared (IR) laser running at 2.94 μm wavelength. Approximately 12 mm above the sample surface, the ablation plume is intercepted with an orthogo...
متن کاملElectron capture atmospheric pressure photoionization mass spectrometry: analysis of fullerenes, perfluorinated compounds, and pentafluorobenzyl derivatives.
An electron capture (EC) ionization mechanism has been found to be highly efficient in negative-ion atmospheric pressure photoionization (APPI) for the analysis of compounds with positive electron affinity (EA). Using negative-ion APPI, we first report the sensitive detection of natural electrophores with limited polarity, such as fullerenes and perfluorinated compounds, by mass spectrometry (M...
متن کاملAnalysis of chlorothalonil by liquid chromatography/mass spectrometry using negative-ion atmospheric pressure photoionization.
A highly sensitive and simple method for the analysis of chlorothalonil was presented using a liquid chromatograph/mass spectrometer equipped with an atmospheric pressure photoionization (APPI) source. Chlorothalonil is one of the most extensively used fungicides. The major degraded product of chlorothalonil, 4-hydroxy-2,5,6-trichloroisonaphthonitrile (4OH-TPN), was also quantified with sensiti...
متن کاملAnalysis of nitrogen-based explosives with desorption atmospheric pressure photoionization mass spectrometry.
RATIONALE Fast methods that allow the in situ analysis of explosives from a variety of surfaces are needed in crime scene investigations and home-land security. Here, the feasibility of the ambient mass spectrometry technique desorption atmospheric pressure photoionization (DAPPI) in the analysis of the most common nitrogen-based explosives is studied. METHODS DAPPI and desorption electrospra...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2009
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.129.993